PROBLEM TO BE SOLVED: To provide: conformation specific antibodies to trefoil factor (TFF) and compositions thereof； and methods of regulation of cellular proliferation and/or survival, particularly methods for the treatment of cancers, tumors and proliferative disorders.SOLUTION: The present invention provides antibodies that specifically bind to a TFF1 polypeptide and bind to a conformational epitope on the TFF1 polypeptide. The present invention also provides methods of inhibiting proliferation or survival of a tumor cell, the methods including contacting the cell with the antibodies.【課題】トレフォイル因子（TFF）に対する高次構造特異的抗体及びその組成物、細胞増殖及び/又は生存の調節法、特に癌、腫瘍及び増殖障害の治療法の提供。【解決手段】TFF1ポリペプチドに特異的に結合する抗体であって、該TFF1ポリペプチドの高次構造エピトープに結合する抗体。腫瘍細胞の増殖または生存を阻害する方法であって、前記抗体と接触させる段階を含む方法。【選択図】図８
