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MOLEKULE KOJE VEŽU ANTIGEN I SADRŽE TRIMER TNF LIGAND OBITELJI
专利权人:
F. Hoffmann - La Roche AG
发明人:
Amann, Maria,Bruenker, Peter,Claus, Christina,Ferrara Koller, Claudia,Grau-Richards, Sandra,Klein, Christian,Levitsky, Victor,Moessner, Ekkehard,Regula, Joerg Thomas,Umaña, Pablo
申请号:
HRP20200679
公开号:
HRP20200679T1
申请日:
2020.04.28
申请国别(地区):
HR
年份:
2020
代理人:
摘要:
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to CD19 and (b) a first and a second polypeptide that are linked to each other by a disulfide bond,characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof, wherein the TNF ligand family member is 4-1BBL.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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