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ANTIGENĄ SURIŠANČIOS MOLEKULĖS, APIMANČIOS TNF ŠEIMOS LIGANDO TRIMERĄ
专利权人:
F. Hoffmann-La Roche AG
发明人:
AMANN, Maria,BRUENKER, Peter,CLAUS, Christina,FERRARA KOLLER, Claudia,GRAU-RICHARDS, Sandra,KLEIN, Christian,LEVITSKY, Viktor,MOESSNER, Ekkehard,REGULA, Joerg Thomas,UMANA, Pablo
申请号:
LT15797922
公开号:
LT3224275T
申请日:
2015.11.13
申请国别(地区):
LT
年份:
2020
代理人:
摘要:
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to CD19 and (b) a first and a second polypeptide that are linked to each other by a disulfide bond,characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof, wherein the TNF ligand family member is 4-1BBL.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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