Embodiments of negative pressure wound therapy systems and methods are disclosed. In one embodiment, a system includes a wound dressing, negative pressure source, switch, and control circuitry. The switch can include an actuator that toggles states of first and second pairs of contacts in response to a user input. The control circuitry can supply negative pressure with the negative pressure source when the state of the first pair of contacts is a first state and the state of the second pair of contacts is a second state, and the control circuitry can disable supply of negative pressure with the negative pressure source when the state of the first pair of contacts is not the first state or the state of the second pair of contacts is not the second state.