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UREA 2-CARBOXAMIDE DERIVATIVES FOR USE IN TREATMENT OF VEGF-DEPENDENT DISEASES
专利权人:
НОВАРТИС АГ (CH)
发明人:
ШНЕЛЛЬ Кристиан Рене (CH)
申请号:
RU2014122198/15
公开号:
RU2014122198A
申请日:
2012.10.31
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The use of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein A is heteroaryl selected from the group consisting of: R is one of the following substituents: (1) unsubstituted or substituted, preferably substituted C-Calkyl, wherein said substituents independently selected from one or more, preferably one to nine of the following groups: deuterium, fluorine, or one or two of the following C-Cycloalkyl groups; (2) optionally substituted C 1-6 cycloalkyl, wherein said substituents are independently selected from one or more, preferably one to four of the following groups: deuterium, C 1-6 alkyl (preferably methyl), fluoro, cyano, aminocarbonyl; (3) optionally substituted phenyl, wherein said substituents are independently selected from one or more, preferably one or two of the following groups: deuterium, halogen, cyano, C-Calkyl, C-Calkylamino, di (C-Calkyl) amino, C-Calkylaminocarbonyl, di (C-Ci-alkyl) aminocarbonyl, C-Ci-alkoxy; (4) an optionally mono- or disubstituted amine, wherein said substituents are selected from the following groups: deuterium, C-C1-6 alkyl (which is unsubstituted or substituted with one or more substituents selected from the group consisting of deuterium, fluorine, chlorine, hydroxy), phenylsulfonyl ( which is unsubstituted or substituted by one or more, preferably one C 1 -C 6 alkyl, C 1 -C 2 alkoxy, di (C 1 -C 1 alkyl) amino-1-C 1 alkoxy); (5) substituted sulfonyl, wherein said substituent is selected from the following groups: C-C1-6 alkyl (which is unsubstituted or substituted by one or more substituents selected from the group consisting of deuterium, fluorine), pyrrolidino, (which is unsubstituted or substituted by one or more �1. Применение соединения формулы (I):или его фармацевтически приемлемой соли, гдеA представляет собой гетероарил, выбранный из группы, состоящей из:Rпредставляет собой один из следующих заместителей: (1) незамещенный или замещенный, предпочтительно замещенный C-Cалкил, где указа
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