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תכשירים נוזליים למתן של אתאנרספט
专利权人:
SUK YOUNG CHOI;YOUN KYUNG KO;JIN EON SO;LG LIFE SCIENCES LTD.
发明人:
SUK YOUNG CHOI,YOUN KYUNG KO,JIN EON SO
申请号:
IL22978713
公开号:
IL229787A
申请日:
2013.12.03
申请国别(地区):
IL
年份:
2016
代理人:
摘要:
The present invention relates to a stable liquid formulation of etanercept (recombinant p75 sTNFR:Fc fusion protein), and more particularly, to a liquid formulation comprising one or more stabilizers selected from the group consisting of methionine, lysine, histidine, and pharmaceutically acceptable salts thereof in an amount sufficient to reduce by-product formation of etanercept during storage. The liquid formulation according to the present invention effectively reduces production of etanercept by-products and to stably maintain its pharmaceutical efficacies for long-term storage. Therefore, the reconstitution procedure is not required before administration, and the sterile formulation can be administered to patients to ensure patient safety. Thus, it can be applied to the fields in need of etanercept treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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