A decongestant composition is provided comprising: (a) a safe and effective amount of an adrenergic compound； (b) a safe and effective amount of a steroid； and (c) a pharmaceutically-acceptable carrier. Methods of treating congestion in a human or animal subject are also provided comprising administering to the subject a composition comprising: (a) an adrenergic compound； and (b) a steroid； where the daily dose of the adrenergic compound administered to the subject is from about 1 μg to about 800 μg, and the daily dose of the steroid administered to the subject is from about 1 μg to about 400 μg.
