МОНИЯ Бретт П. (US),КРОСБИ Джеффри Р. (US),МАКЛЕОД Роберт А. (US),ФРЕЙЕР Сьюзан М. (US)
申请号：
RU2011146158/15
公开号：
RU2011146158A
申请日:
2010.04.15
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method for modulating an inflammatory response by administering a compound to an animal, wherein the compound comprises a factor XI.2 modulator. The method of claim 1, wherein the factor XI modulator is a modified oligonucleotide targeted to factor XI. A method for improving an inflammatory disease, disorder or condition in an animal, comprising administering to the animal a compound targeted at factor XI, wherein the compound administered to the animal improves the inflammatory disease, disorder or condition in the animal. 4. A method of treating an animal at risk of an inflammatory disease, disorder or condition, comprising administering to the animal a therapeutically effective amount of a compound targeted to factor XI, wherein the compound administered to the animal treats an inflammatory disease, disorder or condition in the animal. A method of inhibiting the expression of factor XI in an animal suffering from an inflammatory disease, disorder or condition, comprising administering to the animal a compound targeted to factor XI, wherein the compound administered to the animal inhibits the expression of factor XI in an animal suffering from an inflammatory disease, disorder or condition. A method for reducing the risk of an inflammatory disease, disorder or condition in an animal, comprising administering to the animal a compound targeted to factor XI, wherein the compound administered to the animal reduces the risk of an inflammatory disease, disorder or condition in the animal. The method according to claim 1, 3, 4, 5 or 6, where factor XI has the sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2.8. The method according to claim 3, 4, 5, or 6, wherein the compound targeted to factor XI is modified1. Способ модуляции воспалительной реакции посредством введения соединения животному, где соединение содержит модулятор фактора XI.2. Способ по п.1, где модулятор фактора XI представляет собой модифицированный олигонуклеотид, нацеленный на фактор XI.3. Способ улучш
