NADPH oxidase 4 inhibitors and use thereof

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专利权人:

GenKyoTex Suisse SA

发明人:

BRANDES, Ralf,SCHRÖDER, Katrin,PAGE, Patrick,LALEU, Benoît,GAGGINI, Francesca

申请号：

ES12798879

公开号：

ES2638596T3

申请日:

2012.11.09

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A Nox4 inhibitor (NADPH oxidase 4) for use in the prevention and / or treatment of osteoclastogenic dysfunction related to an increase in bone turnover or bone resorption of secondary cause and / or osteoporosis, in which said Nox4 inhibitor is select from the following group: 4- (2-fluoro-4-methoxyphenyl) -2- (2-methoxyphenyl) -5- (pyridin-3-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3, 6 (2H, 5H) -dione； 2- (2-Chlorophenyl) -4- (4-methoxyphenyl) -5- (pyrazin-2-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -dione； 4- (4-chlorophenyl) -2- (2-methoxyphenyl) -5- (pyrazin-2-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -dione； 2- (2-Chlorophenyl) -4- (2-fluoro-4-methoxyphenyl) -5 - [(1-methyl-1H-pyrazol-3-yl) methyl] -1H-pyrazolo [4,3-c] pyridine -3.6 (2H, 5H) -dione； 4- (2-Fluoro-5-methoxyphenyl) -2- (2-methoxyphenyl) -5- (pyridin-3-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -diona； 2- (2-Chlorophenyl) -5 - [(2-methoxypyridin-4-yl) methyl] -4-methyl-1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -dione； 2- (2-Methoxyphenyl) -4-methyl-5- (pyridin-3-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -dione； 4- (4-Chloro-2-fluorophenyl) -2- (2-methoxyphenyl) -5- (pyridin-3-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -diona； 4- (5-Chloro-2-fluorophenyl) -2- (2-chlorophenyl) -5- (pyridin-3-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -diona； 2- (2-Chlorophenyl) -5 - [(6-methoxypyridin-3-yl) methyl] -4-methyl-1H-pyrazol lo [4,3-c] pyridine-3,6 (2H, 5H) -dione ； 4- (4-Chloro-2-fluorophenyl) -2- (2-chlorophenyl) -5- (pyridin-3-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -diona； 4- (5-Chloro-2-fluorophenyl) -2- (2-chlorophenyl) -5- (pyridin-4-ylmethyl) -1H-pyrazolo [4,3-c] pyridine-3,6 (2H, 5H) -diona； 4- (2-Fluoro-5-methoxyphenyl) -2- (2-methoxyphenyl) -5 - [(1-methyl-1H-pyrazol-3-yl) methyl] -1H-pyrazolo [4,3-c] pyridine -3.6 (2H, 5H) -dione； 4- (5-Chloro-2-fluorophenyl) -2- (2-methoxyphenyl) -5- (pyridin-3-ylmethyl) -1H-pyrazolo [

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