PARONE, PHILIPPE A.,TACKE, ROBERT S.,VALAMEHR, BAHRAM,SHOEMAKER, DANIEL,HOSKING, MARTIN,GUERRETTAZ, LISA
申请号：
CA3068604
公开号：
CA3068604A1
申请日:
2018.06.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Compositions and methods for manufacturing induced immune regulatory cells comprising induced myeloid suppressive cells including MDSCs (myeloid-derived suppressor cells), dendritic cells, macrophages, and subpopulations thereof are provided. Also provided are methods and compositions for further modifying and modulating the induced immune regulatory cells to achieve enhanced therapeutic potential in treating autoimmune disorders, hematological malignancies, solid tumors, viral infections, neurodegenerative disorders, inflammatory conditions, or GvHD.
