INHIBITEURS DE LA DIMERISATION DE GALECTINES PROTOTYPIQUES ET LEUR UTILISATION

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专利权人:

INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人:

CHATENET, DAVID,DOUCET, NICOLAS,ST-PIERRE, YVES,VLADOIU, MARIA-CLAUDIA

申请号：

CA2986927

公开号：

CA2986927A1

申请日:

2016.05.25

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Agents that inhibit the dimerization of a prototypic galectin such as galectin-7 are described. These agents, for example antibodies and peptides, bind to a domain corresponding to residues 13-25, 86-108 and/or 129-135 of human galectin-7. The use of such agents to inhibit a biological, physiological and/or pathological process that involves prototypic galectin dimerization, for example for the inhibition of galectin-7-mediated apoptosis and the treatment of galectin-7-expressing cancers, is also described.

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