Aurash Shahripour;Haifeng Tang;Shawn P. Walsh;Lihu Yang;Nardos H. Teumelsan;Alexander Pasternak;Yuping Zhu
发明人:
Alexander Pasternak,Aurash Shahripour,Haifeng Tang,Nardos H. Teumelsan,Lihu Yang,Yuping Zhu,Shawn P. Walsh
申请号：
US12768209
公开号：
US08673920B2
申请日:
2010.04.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention relates to compounds having structural Formula I:and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
