Alexander Pasternak,Yuping Zhu,Aurash Shahripour,Haifeng Tang,Lihu Yang,Shawn P. Walsh,Nardos H. Teumelsan
申请号：
US14162963
公开号：
US09018211B2
申请日:
2014.01.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention relates to compounds having structural Formula I:and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
