The present invention relates to new histamine H3 (H3) receptor subtype selective ligands of the general formula (I) and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and the use of these compounds as medicaments for treatment and/or prevention of conditions which require modulation of H3 receptors. The invention also cover the combinations of a compound of the general formula (I) and an acetylcholinesterase inhibitor.本發明係關於通式(I)之新組織胺H3(H3)受體亞型選擇性配位體及/或其幾何異構物及/或立體異構物及/或非鏡像異構物及/或鹽及/或水合物及/或溶劑合物。本發明另外係關於含有該等化合物之醫藥組成物，及此等化合物作為用於治療及/或預防需要調節H3受體之病況的藥物之用途。本發明也涵蓋通式(I)化合物及乙醯膽鹼酯酶抑制劑的組合物。
