The invention relates to 1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazole compounds of the FormulaI:or a tautomer, stereoisomer, or pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.本發明係關於式I之1-(芳基磺醯基)-4-(哌-1-基)-1H-苯并咪唑化合物:或其互變異構體、立體異構體或醫藥上可接受之鹽,其中組成變量係如本文所定義;包含該等化合物之組合物;及製備及使用該等化合物之方法。