BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS

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专利权人:

PFIZER

发明人:

ANDERSON DAVID RANDOLPH,BUNNAGE MARK EDWARD,CURRAN KEVIN JOSEPH,DEHNHARDT CHRISTOPH MARTIN,GAVRIN LORI KRIM,GOLDBERG JOEL ADAM,HAN SEUNGIL,HEPWORTH DAVID,HUANG HORNG-CHIH,LEE ARTHUR,LEE KATHERINE LIN

申请号：

AP2016009514

公开号：

AP2016009514A0

申请日:

2015.03.26

申请国别(地区):

AP

年份:

2016

代理人:

摘要：

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), methods of synthesis, and intermediates are also disclosed.

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