DANA-FARBER CANCER INSTITUTE, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人:
WALENSKY, LOREN D.,VERDINE, GREGORY,KORSMEYER, STANLEY J., (DECEASED)
申请号：
CA2830063
公开号：
CA2830063C
申请日:
2004.11.05
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
