Loren D. Walensky;Stanley J. Korsmeyer;Susan Korsmeyer;Gregory Verdine
发明人:
Loren D. Walensky,Stanley J. Korsmeyer,Gregory Verdine
申请号：
US13252751
公开号：
US09273099B2
申请日:
2011.10.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
