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DERIVATIVES OF α-SUBSTITUTED GLYCINEAMIDE
专利权人:
KISSEI FARMASYUTIKAL KO.; LTD.
发明人:
KHIRASAVA, Khideaki (JP),ХИРАСАВА, Хидеаки (JP),KAVAMURA, Naokhiro (JP),КАВАМУРА, Наохиро (JP),KOBAYASI, Dzuniti (JP),КОБАЯСИ, Дзунити (JP)
申请号:
RU2015152201
公开号:
RU0002670982C2
申请日:
2014.05.07
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein A1 is a group selected from the group consisting of the following items a) to c), where a) C6 aryl, where the ring is unsubstituted or substituted with 1 or 2 substituents independently selected from the group comprising a halogen atom, hydroxy, C1-6 alkyl, C1-6 alkoxy, halogen-C1-6 alkyl, C1-6 alkoxycarbonyl, cyano, hydroxy-C1-6 alkyl, carbamoyl, nitro, amino, C1-6 alkoxycarbonylamino-C1-6 alkyl, mono(di)C1-6 alkylamino, (C1-6 alkyl)carbonylamino, C1-6 alkylsulphonylamino and C1-6 alkylsulphonyl; b) thiazolyl, and c) a group selected from the group consisting of pyridyl, pyrimidinyl, pyrazinyl and pyridazinyl, where the ring is unsubstituted or substituted with 1 or 2 substituents independently selected from the group comprising a halogen atom, hydroxy, C1-6 alkyl, C1-6 alkoxy, halogen-C1-6 alkyl, cyano and halogen-C1-6 alkoxy; A2 is a group selected from the group including the following items d) to f), where d) C6-10 aryl, in which the ring is unsubstituted or substituted with 1 or 2 substituents independently selected from the group including: halogen atom, hydroxy, C1-6 alkyl, C1-6 alkoxy, hydroxy-C1-6 alkoxy, halogen-C1-6 alkyl, halogen-C1-6 alkoxy, cyano, amino, nitro, carboxy, (C1-6 alkyl)carbonylamino, (C1-6 alkyl) carbonyloxy, (C1-6 alkyl)carbonyl and (C7-10 aralkyloxy)carbonyl; e) a group consisting of thienyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyranyl, pyridyl, 1-oxidopyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, furazanyl, morphonyl, benzothiazolyl, isoquinolyl, quinolyl, 2,3-dihydrobenzofuranyl, imidazo[1,2-a]pyridyl, imidazo[1,2-a]pyrazinyl, benzo[1,3]dioxolyl, benzothienyl, 5,6,7,8-tetrahydroimidazo[1,2- a]pyrazinyl, where the ring is unsubstituted or substituted with 1 or 2 substituents independently selected from the group comprising a halogen atom, hydrox
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