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METHODS FOR PRODUCING ARIPIPRAZOLE SUSPENSION AND FREEZE-DRIED FORMULATION
专利权人:
OTSUKA PHARMACEUTICAL CO.; LTD.
发明人:
HIRAOKA, SHOGO,MATSUDA, TAKAKUNI,HATANAKA, JUNICHI
申请号:
NZ58241508
公开号:
NZ582415A
申请日:
2008.07.30
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed herein is a method for producing an aripiprazole suspension comprising the steps of: a) combining bulk aripiprazole and a vehicle to form a primary suspension b) subjecting the primary suspension to first pulverization to form a secondary suspension and c) subjecting the secondary suspension to a second pulverization to form a final suspension, where in the first pulverization of step b), the secondary suspension is formed by pulverizing the primary suspension using a high sheer pulverizing machine or a dispersion machine that applies shear force to a material to be processed, and in the second pulverization of step c), the final suspension is formed by pulverizing the secondary suspension using a high-pressure homogenizer.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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