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ARIPIPRAZOLO SUSPENSIJOS IR LIOFILIZUOTOS KOMPOZICIJOS GAMYBOS BŪDAI
专利权人:
Otsuka Pharmaceutical Co.; Ltd.
发明人:
HIRAOKA, Shogo,MATSUDA, Takakuni,HATANAKA, Junichi
申请号:
LT08792242
公开号:
LT2170279T
申请日:
2008.07.30
申请国别(地区):
LT
年份:
2018
代理人:
摘要:
Disclosed are a method for producing an aripiprazole suspension, wherein the aripiprazole has a mean particle size of 1 to 10 μm, the method comprising the steps of: (a) combining bulk aripiprazole and a vehicle to form a primary suspension; (b) subjecting the primary suspension to first pulverization using e.g., a high shear pulverizing machine, a dispersion machine that applies shear force to a material to be processed, a colloid mill, an ultrasonic dispersion machine, or a high-pressure jet type emulsifying dispersion machine to form a secondary suspension; and (c) subjecting the secondary suspension to second pulverization using e.g., a high-pressure jet type emulsifying dispersion machine to form a sterile final suspension; and a method for producing a freeze-dried formulation from the aripiprazole suspension.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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