The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.본 발명은 광노화에 의한 주름개선 효과를 갖는 화장료 조성물에 관한 것으로 육두구 가종피(aril of nutmeg)에서 분리된 화학식 1의 2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)-propane과 화학식 2의 아우스토바이리그난 세븐(austobailignan 7)은 주름개선 효과에서 중요한 요인인 콜라겐 분해효소-1(MMP-1, matrix metalloproteinase-1-1) 억제 능력과 신생 콜라겐(collagen) 합성 능력을 나타낸다.[화학식 1][화학식 2]
