The Research Foundation for The State University of New York
发明人:
Daniel RALEIGH,Rehana AKTER,Andisheh ABEDINI
申请号：
US16482471
公开号：
US20190352356A1
申请日:
2018.02.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure provides for isolated non-naturally occurring, mutant-human IAPP polypeptides, which are more soluble at neutral pH than the wild-type hIAPP protein. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject in a single injection with an insulin agent. The present disclosure also provides methods and pharmacological compositions for treating an abnormal condition, such as an amyloid-based disease or type-1 diabetes in a subject.
