The Research Foundation for the State University of New York
发明人:
Daniel RALEIGH,Hui WANG,Ping CAO,Andisheh ABEDINI
申请号：
US16032328
公开号：
US20180319860A1
申请日:
2018.07.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Isolated non-naturally occurring, mutant-human islet amyloid polypeptides (hIAPP) are disclosed. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject having an amyloid-based disease in a single injection with an insulin agent. Methods and compositions for treating amyloid-based disease in a subject in need thereof, by administering an effective amount of an isolated, mutant-hIAPP polypeptide, including formulations or co-formulations thereof are also disclosed.
