#$%^&*AU2015207888A120170216.pdf#####ABSTRACT An apparatus and method to modify the genetic regulation of mammalian tissue, bone, or any combination. The method may be comprised of the steps of tuning at least one 5 predetermined profile associated with at least one time-varying stimulation field thereby resulting in at least one tuned time-varying stimulation field comprised of at least one tuned predetermined profile, wherein said at least one tuned predetermined profile is comprised of a plurality of tuned predetermined figures of merit and is controllable through at least one of the plurality of tuned predetermined figures of merit, wherein the plurality of predetermined 10 tuned figures of merit is comprised of a tuned B-Field magnitude, tuned rising slew rate, tuned rise time, tuned falling slew rate, tuned fall time, tuned frequency, tuned wavelength, and tuned duty cycle； and exposing mammalian chondrocytes, osteoblasts, osteocytes, osteoclasts, nucleus pulposus, associated tissue, or any combination to said at least one tuned time-varying stimulation field comprised of the at least one tuned predetermined profile 15 for a predetermined tuned exposure.1/8 10 B-Field f 9-200Hz +0.6......... ......... . Q Q 1 ' 3 20OaG =---sing sgsw w .s trite 0 SV 01 tme -0.6- ) ) 200G A= 500ms FIG. 1
