Jee Won AHN,Kwan Young KO,Jeong Hye YOON,Seung-Ho BAEK,Min Jung KIM,Geun Hye YEO,Jeong-Ae LIM,Soo-kwang KIM
申请号：
US16758386
公开号：
US20200247843A1
申请日:
2018.10.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed is a method for preparing a composition comprising factor VIII (FVIII) and von Willebrand factor (vWF), wherein the content of the von Willebrand factor (vWF) can be controlled by mixing the factor VIII (FVIII) with the von Willebrand factor (vWF) at an appropriate ratio after separately purifying the factor VIII (FVIII) and the von Willebrand factor (vWF) from plasma in a single process. The method can prepare and purify a composition comprising factor VIII (FVIII) and a varying content of von Willebrand factor (vWF) without increasing the amount of impurities other than the von Willebrand factor (vWF) compared to a method of purifying factor VIII (FVIII) separately, without significantly increasing the processing time (within 3 hours) compared to a method of purifying factor VIII (FVIII), and without changing the yield of factor VIII (FVIII).
