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MODULATEURS PEPTIDIQUES DE L'INTERACTION ENTRE LE PEPTIDE C HUMAIN ET LE RECEPTEUR D'ELASTINE HUMAINE A USAGE THERAPEUTIQUE
专利权人:
BIOTEMPT B.V.
发明人:
WENSVOORT, GERT
申请号:
CA3051293
公开号:
CA3051293A1
申请日:
2018.02.05
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The invention shows that inflammation in metabolic syndrome is augmented by an hitherto overlooked lock- and-key activation of the elastin receptor, a protein involved in vascular (blood vessel) inflammation and elastin repair, with the C-peptide, a small protein that is produced in a 1:1 ratio alongside with widely known insulin. The elastin receptor is the lock that is activated by a key motif of amino acids (PG-domain) found in C-peptide and in breakdown products (PG-domain-fragments) thereof. Until now, no one has ever discovered this lock-and-key interaction between the two, now providing novel development of novel peptides for treatment of metabolic syndrome, exploiting the finding that not only the normal keys of the elastin receptor (elastin peptides), but also the C-peptide, a peptide we produce together with insulin every time glucose rises in our blood after a meal, interacts in a lock-and-key mode with the elastin receptor.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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