Robert I. HIGUCHI,Tucker Curran ROBERTS,Peter Andrew SMITH,David CAMPBELL,Prasuna PARASELLI
申请号：
US14631762
公开号：
US20150166605A1
申请日:
2015.02.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
