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Indole derivative and pharmacologically acceptable salt thereof
专利权人:
Tatsuhiro Kondo;Yasushi Kohno;Kazuya Tatani;Naohiro Kawamura;Shigeki Seto;Atsushi Kondo
发明人:
Kazuya Tatani,Atsushi Kondo,Tatsuhiro Kondo,Naohiro Kawamura,Shigeki Seto,Yasushi Kohno
申请号:
US13980604
公开号:
US08815903B2
申请日:
2012.01.24
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism:wherein A represents a benzene ring, a pyridine ring, or the like; Y1 represents a C1-6 alkylene group or the like; Y2 represents a single bond or the like; Z represents —C(═O)—NHSO2R6, an acidic 5-membered hetero ring group, or the like; R1 represents a hydrogen atom or the like; R2 represents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.
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