CENTRO DE INVESTIGACION Y DE ESTUDIOS AVANZADOS DEL I. P. N.
发明人:
JUAN BAUTISTA KOURI FLORES,JOSÉ RAYMUNDO CRUZ PÉREZ
申请号：
MX2011008969
公开号：
MX361192B
申请日:
2011.08.24
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
The present invention relates to methods of detection and treatment of osteoarthritis (OA) at early stages of development of the disease through the detection and neutralization of IL1 ß as an early biomarker of OA. The method of the invention also refers to the relationship of the expression of pro-inflammatory and anti-inflammatory cytokines in healthy cartilage and osteoarthritic cartilage as a mean to assess the role IL-1ß as a potential biomarker of early OA. The present invention also provides efficient methods for treating OA at early stages by using inhibitors of IL-1ß activity in the cartilage, thereby preventing the progression of OA to stages of difficult treatment or to reverse the damage on the cartilage by the presence of IL-1ß.La presente invención se refiere a un anticuerpo monoclonal neutralizante de la actividad de IL-1ß para usarse a una concentración de 25 a 50 µg/mL para detener la progresión de la degradación del cartílago actual.
