University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Xiangqun Xie
申请号：
US15580643
公开号：
US20180265452A1
申请日:
2016.06.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A compound, or a pharmaceutically acceptable salt thereof, having a formula I of:wherein Ar is an arylene or heteroarylene；R1 has a structure of:wherein W is an alkanediyl, alkenediyl, a carbonyl, or a combination thereof；X is —NR5—, wherein R5 is H or an alkyl, or —O—； andY is optionally-substituted cycloalkyl, optionally-substituted cycloalkyl-substituted alkyl, optionally-substituted heterocycloalkyl, or optionally-substituted heterocycloalkyl-substituted alkyl；each R2 is the same or different and has a structure of:wherein Z is —NR6—, wherein R6 is H or an alkyl, —O—, —S—, or —CH2—；Z1 is (—CH2—)m wherein m is 0 to 5, or an alkenediyl having 2 to 6 carbon atoms；Cy is a 3-8-membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring； andeach R4 is the same or different and is selected from hydroxy, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, or amino； and c is 0 to 5； andeach R3 is the same or different and is selected from hydroxy, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, amino, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or a nitro,wherein a is 2 to 5, and b is 0 to 3.
