Universite Libre de Bruxelles;Institut Jules Bordet
发明人:
Ghanem, Ghanem,Journe, Fabrice,Krayem, Mohammad,Awada, Ahmad
申请号：
AU2015239108
公开号：
AU2015239108A1
申请日:
2015.04.01
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention relates to a p53-activating agent capable of transferring wild-type tumor protein p53 (p53) from an inactive conformation into an active conformation capable of inducing apoptosis, for use in the treatment of melanoma, wherein said p53-activating agent is administered simultaneously or sequentially with a BRAF-inhibiting agent capable of inhibiting activity of serine/threonine-protein kinase B-Raf (BRAF) comprising an activating mutation.
