As for this invention, can be connected to CD160 the antibody which or being the fragment, the said antibody, a) amino acid arrangement below: (i) It is light chain CDR1: QSISNH (arrangement number 1), (ii) it is light chain CDR2: YAS and (iii) it is light chain CDR3: QQSNSWPLT (arrangement number 2) three lightly chain complementary territories which it possesses (CDR), and the immunoglobulin lightly it is light the chain which includes lightly the chain framework arrangement of chain origin And b) Amino acid arrangement below: (i) It is heavy chain CDR1: GYTFTDYW (arrangement number 3), (ii) it is heavy chain CDR2: IYPGDDDA (arrangement number 4) (iii) It is heavy chain CDR3: ARRGIAAVVGGFDY (arrangement number 5) three it is heavy chain complementary territories which it possesses (CDR) And the immunoglobulin heavily heavily the antibody which includes the chain which includes heavily the chain framework arrangement of chain origin or the fragment The condition which it is related to the multiplication of the endotherium which participates in the medicine and the blood vessel formation process which include the said antibody remedy and/or use of the said antibody for manufacturing the medicine in order to prevent, it regards.< Selective figure >It is not本発明は、CD160に結合できる抗体又はその断片であって、該抗体が、a)以下のアミノ酸配列:(i)軽鎖CDR1:QSISNH(配列番号1)、(ii)軽鎖CDR2:YAS、(iii)軽鎖CDR3:QQSNSWPLT(配列番号2)を有する3つの軽鎖相補性領域(CDR)、及び免疫グロブリン軽鎖由来の軽鎖フレームワーク配列を含む軽鎖;及びb)以下のアミノ酸配列:(i)重鎖CDR1:GYTFTDYW(配列番号3)、(ii)重鎖CDR2:IYPGDDDA(配列番号4);(iii)重鎖CDR3:ARRGIAAVVGGFDY(配列番号5)を有する3つの重鎖相補性領域(CDR);及び免疫グロブリン重鎖由来の重鎖フレームワーク配列を含む重鎖を含む抗体又はその断片;該抗体を含む医薬及び血管形成過程に関与する内皮細胞の増殖に関連する病状を治療及び/又は予防するための医薬の調製のための該抗体の使用、に関する。【選択図】なし
