COUMANS, Rudy Gerardus Elisabeth,SPIJKER, Henri Johannes
申请号：
LT17705364
公开号：
LT3458100T
申请日:
2017.02.13
申请国别(地区):
LT
年份:
2020
代理人:
摘要：
The present invention relates to a process for the selective reduction of cysteine- engineered antibodies comprising reacting an antibody comprising one or more engineered cysteines at positions selected from HC40, HC41,HC42, HC89, HC152, HC153, HC155, HC171, LC40, LC41, LC165, and LC168 with a compound according to formula (I), (II), (III), (IV), (V), (VI) or (VII): (I) (II) (III) (IV) (V) (VI) (VII), and to a process for the preparation of antibody conjugates, including antibody-drug conjugates (ADCs).
