PROBLEM TO BE SOLVED: To provide a medicinal liquid modifier solution suitable for preparing a water-based medicinal liquid especially water-based eye drops, capable of suppressing proliferation of microorganisms without adding any stimulative antiseptic, and to provide a method for preparing the medicinal liquid.SOLUTION: The water-based medicinal liquid modifier usable for preparing eye drops and the like is provided. A composition practically containing no stimulative antiseptic is obtained by using borate ion and phosphate ion together and adjusting to be pH6.5-8.0 so as to have antiseptic action (microbial proliferation suppressing action) and not to practically contain any stimulative antiseptic. The coexisting molar ratio of the borate ion and the phosphate ion is preferably the former/the latter=1/5 to 6/1.COPYRIGHT: (C)2007,JPO&INPIT【課題】刺激性防腐剤を添加しなくても、微生物の増殖を抑制できる水性薬液、特に、水性点眼液を調製するのに好適な薬液調製液及び薬液調製方法を提供すること。【解決手段】点眼薬等の調製に使用する水性薬液用調製剤。ホウ酸イオン及びリン酸イオンとを共存させ、かつ、pH6.5~8.0に調節して、防腐作用(菌増殖抑制作用)を有するようにして、刺激性防腐剤を実質的に含有しない組成とする。ホウ酸イオンとリン酸イオンの共存モル比で、前者/後者=1/5~6/1が望ましい。【選択図】なし
