MURPHY, MICHAEL PATRICK,SMITH, ROBIN ANDREW JAMES,HARTLEY, RICHARD CHARLES
申请号:
CA2931000
公开号:
CA2931000A1
申请日:
2014.11.21
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The invention relates to compounds having Formula (1): A-L-B or pharmaceutically acceptable salts thereof, wherein: A is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; L is an optional linker moiety; and B is a mitochondrial targeting moiety. The invention also relates to pharmaceutical compositions containing such compounds and salts, and to the use of such compounds and salts for treating diabetes, preferably hyperglycaemic diabetes. A mass spectrometry probe and to a method of labelling a biological molecule 1 for mass spectrometry detection are also described.