The purpose of the present disclosure is to provide a method for suppressing retinal fibrosis. The present inventors have found that retinal fibrosis can be suppressed by using an anti-endoglin antibody and a VEGF inhibitor in combination. Thus, provided is a suppressing agent for retinal fibrosis, which comprises an anti-endoglin antibody or an antigen-binding fragment thereof that is used in combination with a VEGF inhibitor. The suppressing agent can be used for the treatment of, for example, an ophthalmic disease associated with retinal fibrosis.本發明之目的在於提供一種視網膜纖維化之抑制方法。本發明人等發現，藉由併用抗內皮糖蛋白抗體及VEGF抑制劑，能夠抑制視網膜纖維化。因此，本發明提供一種與VEGF抑制劑併用之包含抗內皮糖蛋白抗體或其抗原結合性片段之視網膜纖維化之抑制劑。該等抑制劑例如能夠用於伴隨視網膜纖維化之眼部疾病之治療。
