COMPOSITION POUR LE TRAITEMENT DU DIABETE COMPRENANT UN CONJUGUE D'INSULINE A ACTION PROLONGEE ET UN CONJUGUE DE PEPTIDE INSULINOTROPIQUE A ACTION PROLONGEE
WOO, YOUNG EUN,JANG, MYUNG HYUN,PARK, YOUNG JIN,PARK, YOUNG KYUNG,LIM, CHANG KI,KWON, SE CHANG
申请号：
CA2837856
公开号：
CA2837856A1
申请日:
2012.06.01
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.
