Formula[In formula, as for R1 hydrogen atom, showing carbon atomic several 1 - 4 alkyl groups or the arukeniru basis carbon atomic several 2 - 4,As for X the ethylene basis, the trimethylene basis, the biniren basis and the echiniren basis or - SCH2 showing the basis which is shown with -,R2, R3 the respective hydrogen atom and the halogen atom, carbon atomic several 1 - 6 alkyl groups, carbon atomic several 1 - 6 halo alkyl groups and carbon atomic several 1 - 6 alkyl groups which are substituted with carbon atomic several 1 - 6 alkoxy groups and carbon atomic several 1 - 6 alkoxy groups, phenyl group and substitution phenyl group, shows the frill basis or the chieniru basis.]So the professional star Glan gin derivative which is displayed, the salt which the medicine manufacture study is allowed or that hydrate while in order to make the side effect decrease which feels concern with the EP4 operation medicine, possessing sufficient anti- inflammation action, is the chemical compound whose cAMP production reinforcement action is weak.式[式中、R1は水素原子、炭素原子数1~4個のアルキル基または炭素原子数2~4個のアルケニル基を示し、Xはエチレン基、トリメチレン基、ビニレン基、エチニレン基または ―SCH2- で示される基を示し、R2、R3はそれぞれ水素原子、ハロゲン原子、炭素原子数1~6個のアルキル基、炭素原子数1~6個のハロアルキル基、炭素原子数1~6個のアルコキシ基、炭素原子数1~6個のアルコキシ基で置換された炭素原子数1~6個のアルキル基、フェニル基、置換フェニル基、フリル基またはチエニル基を示す。]で表されるプロスタグランジン誘導体、その製薬学的に許容される塩またはその水和物は、EP4作動薬で懸念される副作用を低減させるために、十分な抗炎症作用を有しながら、cAMP産生増強作用が弱い化合物である。
