COMPOSITIONS OF AMICACIN AND PHOSPHOMYCIN COMBINATIONS, METHODS AND SYSTEMS FOR TREATMENT OF FAN-ASSOCIATED PNEUMONIA AND FAN-ASSOCIATED TRACHEOBROSHIT
1. A pharmaceutical composition comprising a bactericidal concentration of amikacin and fosfomycin, combined in a hypertonic solution in the ratio of amikacin: fosfomycin in excess of 1: 1, and containing at least about 30 equiv / l of penetrating anion. The composition of claim 1, wherein the osmotic concentration of the solution is less than about 1000 mOsm / l. 3. The composition of claim 2, wherein the concentration of amikacin is at least 50 mg / ml. The composition of claim 2, wherein the concentration of fosfomycin is at least about 20 mg / ml. A composition according to claim 1, having a pH between about 4.4 and about 7.5.6. The composition of claim 1, wherein the concentration of the penetrating anion is at least about 40 meq / l and the osmotic concentration varies between about 310 mOsm / l and less than about 800 mOsm / l. The composition of claim 2, wherein the solution contains from 100 to 300 mg of fosfomycin. A composition according to claim 2, wherein the solution contains from 150 to 600 mg of amikacin. The composition of claim 1, wherein the fosfomycin is a water soluble salt of fosfomycin. The composition of claim 1, wherein the penetrating anion is chloride. 11. A composition comprising: a first component comprising an isolated portion of amikacin with a concentration of more than 100 mg / ml and a pH between about 4.5 and about 6.0； a second component comprising an isolated portion of at least 40 mg of fosfomycin disodium. 12. The composition of claim 11, wherein the fosfomycin is diluted from powder to form a solution with a concentration of more than 110 mg / ml, and the pH of the solution is about 8.0-9.5.13. The composition of claim 11, wherein the first component and the second component are combined to form a mixture with a pH between 6.9 and 7.4, at least 30 eq / L of the chloride anion and the osmotic1. Фармацевтическая композиция, включающая бактерицидную концентрацию амикацина и фосфомицина, скомбинированных в гипертоническом растворе
