COCKERILL, STUART,MATHEWS, NEIL,WARD, SIMON,LUNN, GRAHAM,PARADOWSKI, MICHAEL,GASCON SIMORTE, JOSE MIGUEL
申请号：
CA2963740
公开号：
CA2963740A1
申请日:
2015.10.06
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH； L is a single bond, C1-3 alkylene, C2-3 alkenylene or C2-3 alkynylene； R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12- membered heteroaryl, each of which is unsubstituted or substituted； Z is halo, C1-6 haloalkyl, nitro, -CN, -N(R2)2, -OR2, -SR2, -S(=0)R2, or -S(=0)2R2； each R2 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted； and m is 0 or 1； and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
