The Board of Regents of the University of Oklahoma
发明人:
Hiroshi Yamada,Chinthalapally Rao
申请号：
US16429978
公开号：
US20190387723A1
申请日:
2019.06.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
An animal model (e.g., mouse) and method of use, and cell culture assay method, for characterizing or screening a test compound for its effect on late onset Alzheimer's disease (LOAD). The test compound may be used as a therapeutic agent for treatment of Alzheimer's disease (AD). The AD animal model may be haploinsufficient for Shugoshin 1 (Sgo1) gene, or may comprise a genetic modification enabling modulation of Sgo1 expression in the brain of the animal when exposed to an Sgo1 expression-modulating compound, such as tamoxifen. After the test compound is administered to the animal model, the presence or amount of an AD biomarker is assessed or measured.
