NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY
发明人:
NATSUME, TORU,ADACHI, SHUNGO,IEMURA, SHUNICHIRO
申请号：
EP08871274
公开号：
EP2246422A4
申请日:
2008.12.04
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
[Objective]To be provided is a gene expression regulation method of regulating expression of a target gene and regulating expression of a target gene product both positively and negatively.[Means to Achieve Objectives]Provided is a polynucleotide or polynucleotide analogue, comprising a nucleotide sequence complementary to at least part of a cis element of mRNA and a nucleotide sequence complementary to part of the 5- and/or 3- untranslated region of the cis element, wherein the polynucleotide or polynucleotide analogue inhibits binding of the cis element-binding factor to the cis element, by binding to at least part of the cis element specifically, based on the sequence specificity of the nucleotide sequence complementary to the untranslated region. The polynucleotide or polynucleotide analogue stabilizes the mRNA and accelerates translation thereof to the gene product or destabilizes it and inhibits translation thereof to the gene product selectively, by inhibiting binding of the cis element-binding factor to the cis element.
