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Ciekla zawiesina zawierajaca przeciwgrzybiczo skuteczna ilosc posakonazolu oraz zastosowanie zmikronizowanych czastek posakonazolu
专利权人:
SCHERING CORPORATION
发明人:
SHARPE STEFAN,SEQUEIRA JOEL,HARRIS DAVID,MAHASHABDE SHASHANK
申请号:
PL36396502
公开号:
PL212985B1
申请日:
2002.04.01
申请国别(地区):
PL
年份:
2012
代理人:
摘要:
The invention provides a liquid suspension comprising an antifungally effective amount of the micronized compound represented by the chemical structural formula I: at least one thickening agent, at least one non-ionic surfactant, and a pharmaceutically acceptable liquid carrier. The invention also provides a dosing unit comprising the compound of chemical structural Formula I for use as a medicament, wherein the compound of chemical structural Formula I is micronized to a mean particle size of 1000 nm to 1800 nm, and the dosing unit comprises at least one thickening agent, at least one non-ionic surfactant, and a pharmaceutically acceptable liquid carrier, and comprises the compound of chemical structural formula I in an amount of 200 mg per 5 ml dose. The invention also provides a method of making a suspension of the micronized compound of chemical structural Formula I employing the following ingredients: Ingredient Concentration Range (mg/ml) Coumpound of Formula I (micronized) 10-100 Polysorbate 80 5-50 Sodium Citrate 0.4-0.8 Citric Acid 0.36-0.6 Simethicone 2-4 Xanthan Gum 1-5 Sodium Benzoate 0.5-3 Liquid Glucose 200-500 Glycerin 50-150 Artificial Cherry Flavor 2-10 Titanium Dioxide 2-6 Purified Water wherein water, 40% of the polysorbate 80 and 40% of the simethicone are mixed, water is added, the compound of Formula I is added, and the mixture is micronized; water and the remainder of polysorbate 80 and simethicone are added and mixed; sodium benzoate, sodium citrate, citric acid and xanthan gum are added and mixed; glycerin is added and mixed; liquid glucose is added and mixed; titanium dioxide is added and mixed; artificial cherry flavor is added and mixed; and the remaining water to final volume is added and mixed.
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