A portable physiological parameter detection device comprises: a detection module, configured to detect physiological parameters of a human body, and a power supply module, configured to supply power to the detection module, wherein the power supply module comprises a power generation unit, the power generation unit comprises two electrode layers arranged opposite to each other, an insulation layer is provided on each of surfaces that face each other of the two electrode layers, and the two insulation layers are in close contact with each other. The detection device produces relatively low pollution when being discarded. A portable physiological parameter detection method is further provided.