#$%^&*AU2018267578A120181206.pdf#####ABSTRACT The invention provides methods, compositions, and kits containing phentolamine for improving visual performance. In particular, the invention provides improvement in visual performance, such as improvement in visual acuity, by daily ophthalmic administration of a phentolamine solution to an eye of a patient at or near the bedtime of the patient for an extended duration while minimizing the occurrence of adverse side effects, such as eye redness during the patient's waking hours. See Fig. 1.WO 2014/121028 PCT/US2014/014070 1113 .2 .2 (U (U U) U) E E (U (U CZC 45h Li, NE 'AA CDO 00 ~~rn IN CD 101 0-018-10160,'0'0 ;..oU') ) L C) n 0Ln 0Ln I* Kt Z40 S) PA~jdul 1!m aA310N