#$%^&*AU2018203658A120180614.pdf#####ABSTRACT A compound of formula: RP R1 R4 R110 R3 R2 X wherein Ri, R2, R3 and R4 are independently selected from hydrogen and C-C6 alkyl； R9 is selected from hydrogen or alkyl； Rn is selected from H, C1-C6 alkyl, a sulfate, a glucoronide, and -OSO2alkyl； X is selected from -(CH2)m-O-(CH2)nCH3,-(CH2)m-S-(CH2)nCH3, and -(CH2)m-NH-(CH2)nCH3； Y is selected from hydrogen, =0, and -OH； m is an integer between 2-20； n is an integer between 0-8； the --- symbol represents either a single or a double bond capable of forming a keto group at position 17； and the "% symbol represents any type of bond regardless of the stereochemistry； and the respective enantiomers, stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts thereof.
