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DERIVATIVES OF 5,6-BISARIL-2-PIRIDÍN-CARBOXAMIDA, ITS PREPARATION, ITS APPLICATION IN THERAPEUTICS AS ANTAGONISTS OF UROTENSIN II RECEPTORS.
专利权人:
SANOFI
发明人:
ALTENBURGER JEAN-MICHEL,FOSSEY VALERIE,GALTIER DANIEL,PETIT FREDERIC
申请号:
ES09721603
公开号:
ES2375339T3
申请日:
2009.02.05
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compound that responds to formula (I) in which: X and Y independently represent each other a nitrogen atom or a link -CR4-, in which R4 represents a hydrogen atom or a (C1-C4) alkyl group ) or alkoxy; A represents an aryl or heteroaryl group, said aryl or heteroaryl groups being optionally substituted with one or more groups chosen from a halogen atom, a hydroxy group, (C1-C4) alkyl, cycloalkyl (C3-C5), alkoxy (C1- C4) optionally substituted with a (C1-C4) alkoxy group, halogenoalkyl, halogenoalkoxy, a nitrile group; W represents a halogen atom or a halogenoalkyl group; Z represents a (C1-C4) alkylene group optionally substituted with one or more groups chosen from a halogen atom and the (C1-C4) alkyl, hydroxy and (C1-C4) alkoxy groups; B represents a group -NR4R5, in which R4 and R5 independently represent each other a (C1-C4) alkyl group; R1 and R2 represent: * either, R1 represents a hydrogen atom and R2 represents a (C1-C4) alkyl group, * either R1 and R2 together, with the carbon atom to which they are attached, a mono or polycyclic system chosen between: a cycloalkyl (C3-C8) group, a bicyclic group with bridge bonds or a tetracyclic group with bridge links, said system being able to be substituted with one or more hydroxy groups; R3 represents: either a C (O) group R5 with R5 representing a (C1-C4) alkoxy group optionally substituted with a (C1-C4) alkoxy group or a NR6R7 group with R6 and R7 independently of each other representing a hydrogen atom, a (C1-C4) alkyl, cycloalkyl (C3-C5), alkyl (C1-C4) sulfonyl, halogenoalkyl group, * or a -CH2XR8 group with: - X representing an oxygen atom and R8 representing a hydrogen atom or a (C1-C4) alkyl group, - or X representing an NH and R8 group representing a (C1-C4) alkyl, carbonyl (C1-C4) carboxyl or (C1-C4) alkyl group ) sulfonyl, * or a nitrile group (CN); p represents an integer equal to 0 or 1, in the base or salt state of addition to an acid or a base, as well as its enantiomers and diastereoisomers, including
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