Treatments for conditions involving detrimental activity of the enzyme core 2 GlcNAc - T are provided using compounds of the formula IwhereinR1 is H, -OH, C1-6 alkoxy, -NR5R6, or Sac 1R2 is H, -OH, C1-6 alkoxy or Sac 2R3 is H, -OH, C1-6 alkoxy or Sac 3R4 is H, C1-6 alkyl, C1-6 hydroxyalkyl or C1-6-alkoxy-C1-6-alkylR5 is H, C1-6 alkyl or C1-6 acylR6 is H, C1-6 alkyl or C1-6 acylSac 1 Sac 2 and Sac 3 are independently selected saccharide moieties andZ is a steroid moietyor a pharmaceutically acceptable salt, ether or ester form thereof, wherein the condition to be treated is an inflammatory condition selected from ileitis, cholitis, cholecystitis, diverticulitis, gastritis, irritable bowel syndrome, inflammatory bowel disease, Lupus and ulcerative cholitis.
