Expression of immunogenic polypeptide surface layer Bifidobacterium

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专利权人:

国立大学法人神戸大学

发明人:

白川 利朗,堀田 博,片山 高嶺

申请号：

JP2015501435

公开号：

JP6213969B2

申请日:

2014.02.14

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

Provided is a gene for expressing an immunogenic polypeptide on the cell surface of a bifidobacterium, and the gene includes a gene encoding the immunogenic polypeptide, the immunogenic polypeptide includes a predetermined base domain and at least one antigenic peptide, and the at least one antigenic peptide is linked on any of the N-terminal side and the C-terminal side of the base domain. The gene for expressing an immunogenic polypeptide on a cell surface of a bifidobacterium of the present invention can further include a gene encoding a bifidobacterium-derived GNB/LNB substrate-binding membrane protein.

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